Engineered bacteriophages: A panacea against pathogenic and drug resistant bacteria

Engineered bacteriophages: A panacea against pathogenic and drug resistant bacteria

Blog Article

Antimicrobial resistance (AMR) is a major global concern; antibiotics and other regular treatment methods have failed to overcome the increasing number of infectious diseases.Bacteriophages (phages) are viruses that specifically target/kill bacterial hosts without affecting other human microbiome.Phage therapy provides optimism in the current global healthcare scenario with a long history of its applications in humans that has now reached various clinical trials.

Phages in clinical trials have specific requirements of being exclusively lytic, free from toxic genes with an enhanced host range that adds an Aortic stenosis with abnormal eccentric left ventricular remodeling secondary to hypothyroidism in a Bourdeaux Mastiff advantage to this requisite.This review explains in detail the various phage engineering methods and their potential applications in therapy.To make phages more efficient, engineering has been attempted using techniques like conventional homologous recombination, Bacteriophage Recombineering of Electroporated DNA (BRED), clustered regularly interspaced short palindromic repeats (CRISPR)-Cas, CRISPY-BRED/Bacteriophage Recombineering with Both Feline Coronavirus Serotypes 1 and 2 Infected Domestic Cats Develop Cross-Reactive Antibodies to SARS-CoV-2 Receptor Binding Domain: Its Implication to Pan-CoV Vaccine Development Infectious Particles (BRIP), chemically accelerated viral evolution (CAVE), and phage genome rebooting.

Phages are administered in cocktail form in combination with antibiotics, vaccines, and purified proteins, such as endolysins.Thus, phage therapy is proving to be a better alternative for treating life-threatening infections, with more specificity and fewer detrimental consequences.